Directeur : Jean-Antoine Girault / Directrice-adjointe : Fiona Francis
Actualités de l'Institut du Fer à Moulin
2017 - 8th IFM colloquium - "(Re)Constructing the nervous system : Stem cells and beyond"
Postdoctoral Position Available
A 3-year postdoctoral position is available in Team 5 "Serotonin in plasticity and disease" to study the contribution of serotonin and microglia to memory consolidation, and its potential implication in synaptic plasticity.
Applicants must be highly motivated and are required to have a recent Ph.D. in biological or medical science. Experience either in live imaging, cell biology, signal transduction and/or electrophysiology is required.
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Mutation of the α-tubulin Tuba1a leads to straighter microtubules and perturbs neuronal migration.
Brain development involves extensive migration of neurons. Microtubules (MTs) are key cellular effectors of neuronal displacement, which are assembled from α/β-tubulin heterodimers. Mutation of the α-tubulin isotype Tuba1a is associated with cortical malformations in humans. Belvindrah et al. (Team 2) provide detailed in vivo and in vitro analyses of Tuba1a mutants. In mice carrying a Tuba1a missense mutation (S140G), neurons accumulate and glial cells are dispersed along the rostral migratory stream (RMS) in postnatal and adult brains. Live-imaging of Tuba1a mutant neurons revealed slowed migration and increased neuronal branching, which correlated with directionality alterations and perturbed nucleus-centrosome (N-C) coupling. Tuba1a mutation led to increased straightness of newly polymerized MTs, and structural modeling data suggest a conformational change in the α/β- tubulin heterodimer. This work also shows that Tuba8, another α-tubulin isotype previously associated with cortical malformations, has altered function compared to Tuba1a. In resume, Tuba1a plays an essential, non-compensated role in neuronal saltatory migration in vivo, highlighting the importance of MT flexibility in N-C coupling and neuronal branching regulation during neuronal migration. (Belvindrah et al., J. Cell Biol., 2017).
Semaine du cerveau 2017 : conférence inaugurale de l'ICM - Jean-Antoine Girault
"A la recherche des traces de la mémoire dans le cerveau"
Multiscale single-cell analysis reveals unique phenotypes of raphe 5-HT neurons projecting to the forebrain.
Les neurones sérotoninergiques (5-HT) du raphe sont une très petite population de neurones du cerveau dont les fonctions sont très diverses : mémoire, sommeil, prise alimentaire, agressivité, anxiété... Ces fonctions sont sous-tendues par des régions cérébrales différentes (hippocampe, cortex, hypothalamus, amygdale) vers lesquelles les neurones 5-HT projettent leurs axones.
