Institut du Fer-à-Moulin

Unité 839

(http://www.u839.idf.inserm.fr/)

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Fer à Moulin Institute

Director: Jean-Antoine Girault

Co-directors: Patricia Gapar & André Sobel

The Institut du Fer à Moulin (IFM) is a research center devoted to the study of the development and plasticity of the nervous system.

Multidisciplinary approaches from molecules to behavior.
Two complementary objectives:
- to better understand the physiology and pathology of the nervous system.
- to discover new therapeutic approaches.
Multiple medical applications including for neurological and psychiatric illnesses, as well as cancer.
An Inserm building in the center of Paris, close to Pierre and Marie Curie University (UPMC) main campus and Pitié-Salpêtrière Hospital. IFM is part of the "Integrative Biology Federative Research Institute" of UPMC.
Ten research groups on a surface of about 2000 m².
Common scientific and technical facilities: state-of-the-art microscopy and cell imaging facilities, phenotyping facility for rodents including behavioral exploration.
At the heart of a network of local, national and international academic and industrial collaborations, the IFM is actively involved in teaching and training young scientists and medical doctors.
Seven groups are affiliated to the Paris School of Neuroscience.

The IFM international Scientific Advisory Board (SAB) is chaired by Pr. Peter Brophy (Edinburgh) and comprises Dr. Magdalena Götz (Munich), Pr. Chris Henderson (New York), Pr. Dimitri Kullmann (London), and Pr. Michele Solimena (Dresde). The SAB evaluates the Institute and its groups and advises the Directorial Board to achieve its goals of excellence.

Refurbishing of IFM (levels 0-2) was supported by Inserm, the Conseil général d'Ile de France (Neuropôle de Recherche Francilien) and the Bettencourt-Schüller Foundation.

IFM-Access.pdf

Publié le samedi 05 février 2011

FLASH

For more see "Publications"

Some recent publications from IFM groups

Faure C, Ramos M, Girault JA. Pyk2 cytonuclear localization: mechanisms and regulation by serine dephosphorylation. (2013) Cell Mol Life Sci 70:137-52.

Alcacer C, Santini E, Valjent E, Gaven F, Girault JA, Herve D. Galpha(olf) mutation allows parsing the role of cAMP-dependent and extracellular signal-regulated kinase-dependent signaling in L-3,4-dihydroxyphenylalanine-induced dyskinesia. (2012) J Neurosci 32:5900-10.

Baudoin JP, Viou L, Launay PS, Luccardini C, Espeso Gil S, Kiyasova V, Irinopoulou T, Alvarez C, Rio JP, Boudier T, Lechaire JP, Kessaris N, Spassky N, Metin C. Tangentially Migrating Neurons Assemble a Primary Cilium that Promotes Their Reorientation to the Cortical Plate. (2012) Neuron 76:1108-22.

Bazelot M, Simonnet J, Dinocourt C, Bruel-Jungerman E, Miles R, Fricker D, Francis F. Cellular anatomy, physiology and epileptiform activity in the CA3 region of Dcx knockout mice: a neuronal lamination defect and its consequences. (2012) Eur J Neurosci 35:244-56.

Bellone C, Mameli M. mGluR-Dependent Synaptic Plasticity in Drug-Seeking. (2012) Front Pharmacol 3:159.

Bouthour W, Leroy F, Emmanuelli C, Carnaud M, Dahan M, Poncer JC, Levi S. A human mutation in Gabrg2 associated with generalized epilepsy alters the membrane dynamics of GABAA receptors. (2012) Cereb Cortex 22:1542-53.

Cabezas C, Irinopoulou T, Gauvain G, Poncer JC. Presynaptic But Not Postsynaptic GABA Signaling at Unitary Mossy Fiber Synapses. (2012) J Neurosci 32:11835-40.

Chamma I, Chevy Q, Poncer JC, Levi S. Role of the neuronal K-Cl co-transporter KCC2 in inhibitory and excitatory neurotransmission. (2012) Front Cell Neurosci 6:5.

Danglot L, Freret T, Le Roux N, Neme NN, Burgo A, Hyenne V, Roumier A, Contremoulins V, Dauphin F, Bizot JC, Vodjdani G, Gaspar P, Boulouard M, Poncer JC, Galli T, Simmler MC. Vezatin is essential for dendritic spine morphogenesis and functional synaptic maturation. (2012) J Neurosci 32:9007-22.

Despeaux M, Chicanne G, Rouer E, De Toni-Costes F, Bertrand J, Mansat-De Mas V, Vergnolle N, Eaves C, Payrastre B, Girault JA, Racaud-Sultan C. Focal adhesion kinase splice variants maintain primitive acute myeloid leukemia cells through altered wnt signaling. (2012) Stem Cells 30:1597-610.

Devaux S, Poulain FE, Devignot V, Lachkar S, Irinopoulou T, Sobel A. Specific serine-proline phosphorylation and glycogen synthase kinase 3beta-directed subcellular targeting of stathmin 3/Sclip in neurons. (2012) J Biol Chem 287:22341-53.

Diaz SL, Doly S, Narboux-Neme N, Fernandez S, Mazot P, Banas SM, Boutourlinsky K, Moutkine I, Belmer A, Roumier A, Maroteaux L. 5-HT(2B) receptors are required for serotonin-selective antidepressant actions. (2012) Mol Psychiatry 17:154-63.

Erzurumlu RS, Gaspar P. Development and critical period plasticity of the barrel cortex. (2012) Eur J Neurosci 35:1540-53.

Fernandez SP, Gaspar P. Investigating anxiety and depressive-like phenotypes in genetic mouse models of serotonin depletion. (2012) Neuropharmacology 62:144-54.

French CA, Jin X, Campbell TG, Gerfen E, Groszer M, Fisher SE, Costa RM. An aetiological Foxp2 mutation causes aberrant striatal activity and alters plasticity during skill learning. (2012) Mol Psychiatry 17:1077-85.

Fuchs T, Saunders-Pullman R, Masuho I, Luciano MS, Raymond D, Factor S, Lang AE, Liang TW, Trosch RM, White S, Ainehsazan E, Herve D, Sharma N, Ehrlich ME, Martemyanov KA, Bressman SB, Ozelius LJ. Mutations in GNAL cause primary torsion dystonia. (2012) Nat Genet 45:88-92.

Gangarossa G, Longueville S, De Bundel D, Perroy J, Herve D, Girault JA, Valjent E. Characterization of dopamine D1 and D2 receptor-expressing neurons in the mouse hippocampus. (2012) Hippocampus 22:2199-207.

Gaspar P, Lillesaar C. Probing the diversity of serotonin neurons. (2012) Philos Trans R Soc Lond B Biol Sci 367:2382-94.

Girault JA. Integrating neurotransmission in striatal medium spiny neurons. (2012) Adv Exp Med Biol 970:407-29.

Girault JA. Signaling in striatal neurons: the phosphoproteins of reward, addiction, and dyskinesia. (2012) Prog Mol Biol Transl Sci 106:33-62.

Godin JD, Thomas N, Laguesse S, Malinouskaya L, Close P, Malaise O, Purnelle A, Raineteau O, Campbell K, Fero M, Moonen G, Malgrange B, Chariot A, Metin C, Besson A, Nguyen L. p27(Kip1) is a microtubule-associated protein that promotes microtubule polymerization during neuron migration. (2012) Dev Cell 23:729-44.

Goebbels S, Oltrogge JH, Wolfer S, Wieser GL, Nientiedt T, Pieper A, Ruhwedel T, Groszer M, Sereda MW, Nave KA. Genetic disruption of Pten in a novel mouse model of tomaculous neuropathy. (2012) EMBO Mol Med 4:486-99.

Launay JM, Herve P, Callebert J, Mallat Z, Collet C, Doly S, Belmer A, Diaz SL, Hatia S, Cote F, Humbert M, Maroteaux L. Serotonin 5-HT2B receptors are required for bone-marrow contribution to pulmonary arterial hypertension. (2012) Blood 119:1772-80.

Lelievre EC, Plestant C, Boscher C, Wolff E, Mege RM, Birbes H. N-cadherin mediates neuronal cell survival through Bim down-regulation. (2012) PLoS One 7:e33206.

Manceau V, Kremmer E, Nabel EG, Maucuer A. The protein kinase KIS impacts gene expression during development and fear conditioning in adults. (2012) PLoS One 7(8):e43946.

Maroteaux M, Mameli M. Cocaine evokes projection-specific synaptic plasticity of lateral habenula neurons. (2012) J Neurosci 32:12641-6.

Mazot P, Cazes A, Dingli F, Degoutin J, Irinopoulou T, Boutterin MC, Lombard B, Loew D, Hallberg B, Palmer RH, Delattre O, Janoueix-Lerosey I, Vigny M. Internalization and down-regulation of the ALK receptor in neuroblastoma cell lines upon monoclonal antibodies treatment. (2012) PLoS One 7:e33581.

Meffre J, Chaumont-Dubel S, Mannoury la Cour C, Loiseau F, Watson DJ, Dekeyne A, Seveno M, Rivet JM, Gaven F, Deleris P, Herve D, Fone KC, Bockaert J, Millan MJ, Marin P. 5-HT(6) receptor recruitment of mTOR as a mechanism for perturbed cognition in schizophrenia. (2012) EMBO Mol Med 4:1043-56.

Mouton-Liger F, Paquet C, Dumurgier J, Bouras C, Pradier L, Gray F, Hugon J. Oxidative stress increases BACE1 protein levels through activation of the PKR-eIF2alpha pathway. (2012) Biochim Biophys Acta 1822:885-96.

Mouton-Liger F, Paquet C, Dumurgier J, Lapalus P, Gray F, Laplanche JL, Hugon J. Increased cerebrospinal fluid levels of double-stranded RNA-dependant protein kinase in Alzheimer's disease. (2012) Biol Psychiatry 71:829-35.

Narboux-Neme N, Evrard A, Ferezou I, Erzurumlu RS, Kaeser PS, Laine J, Rossier J, Ropert N, Sudhof TC, Gaspar P. Neurotransmitter release at the thalamocortical synapse instructs barrel formation but not axon patterning in the somatosensory cortex. (2012) J Neurosci 32:6183-96.

Paquet C, Mouton-Liger F, Meurs EF, Mazot P, Bouras C, Pradier L, Gray F, Hugon J. The PKR activator PACT is induced by Abeta: involvement in Alzheimer's disease. (2012) Brain Pathol 22:219-29.

Rebsam A, Bhansali P, Mason CA. Eye-specific projections of retinogeniculate axons are altered in albino mice. (2012) J Neurosci 32:4821-6.

Renner M, Schweizer C, Bannai H, Triller A, Levi S. Diffusion barriers constrain receptors at synapses. (2012) PLoS One 7:e43032.

Stacey D, et al. RASGRF2 regulates alcohol-induced reinforcement by influencing mesolimbic dopamine neuron activity and dopamine release. (2012) Proc Natl Acad Sci U S A 109:21128-21133.

Voyatzis S, Muzerelle A, Gaspar P, Nicol X. Modeling activity and target-dependent developmental cell death of mouse retinal ganglion cells ex vivo. (2012) PLoS One 7:e31105.

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