Institut du Fer-à-Moulin

Unité 839

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8- Molecular and Cellular Mechanisms of Cortical Development

Mathias Groszer has been awarded a junior Chair of Excellence from the Paris School of Neuroscience and an Avenir grant from Inserm

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Recent Publications

2012

- Goebbels S, Oltrogge JH, Wolfer S, Wieser GL, Nientiedt T, Pieper A, Ruhwedel T, Groszer M, Sereda MW, Nave KA. Genetic disruption of Pten in a novel mouse model of tomaculous neuropathy. EMBO Mol Med. 2012 4 :486-99.

- French CA, Jin X, Campbell TG, Gerfen E, Groszer M, Fisher SE, Costa RM.An aetiological Foxp2 mutation causes aberrant striatal activity and alters plasticity during skill learning. Mol Psychiatry. 2012 17:1077-85. 2011

2011

Vernes SC, Oliver PL, Spiteri E, Lockstone HE, Puliyadi R, Taylor JM, Ho J, Mombereau C, Brewer A, Lowy E, Nicod J, Groszer M, Baban D, Sahgal N, Cazier JB, Ragoussis J, Davies KE, Geschwind DH, Fisher SE.Foxp2 regulates gene networks implicated in neurite outgrowth in the developing brain. PLoS Genet. 2011 7:e1002145. 2010

2010

- Gaub S, Groszer M, Fisher SE, Ehret G. The structure of innate vocalizations in Foxp2 deficient mouse pups. Genes Brain Behav. 2010 9:390-401.

Goebbels S, Oltrogge JH, Kemper R, Heilmann I, Bormuth I, Wolfer S, Wichert SP, Möbius W, Liu X, Lappe-Siefke C, Rossner MJ, Groszer M, Suter U, Frahm J, Boretius S, Nave KA. Elevated phosphatidylinositol 3,4,5-trisphosphate in glia triggers cell-autonomous membrane wrapping and myelination. J Neurosci. 2010 Jun 30;30(26):8953-64. doi: 10.1523/JNEUROSCI.0219-10.2010.

2009

- Arnold SJ, Sugnaseelan J, Groszer M, Srinivas S, Robertson EJ. Generation and analysis of a mouse line harboring GFP in the Eomes/Tbr2 locus. Genesis 2009 47:775-81.

- Chow DK, Groszer M, Pribadi M, Machniki M, Carmichael ST, Liu X, Trachtenberg JT. Laminar and compartmental regulation of dendritic growth in mature cortex. Nat Neurosci. 2009 Jan 18. [Epub ahead of print]

- Enard W, Gehre S, Hammerschmidt K, Hölter SM, Blass T, Somel M, Brückner MK, Schreiweis C, Winter C, Sohr R, Becker L, Wiebe V, Nickel B, Giger T, Müller U, Groszer M, Adler T, Aguilar A, Bolle I, Calzada-Wack J, Dalke C, Ehrhardt N, Favor J, Fuchs H, Gailus-Durner V, Hans W, Hölzlwimmer G, Javaheri A, Kalaydjiev S, Kallnik M, Kling E, Kunder S, Mossbrugger I, Naton B, Racz I, Rathkolb B, Rozman J, Schrewe A, Busch DH, Graw J, Ivandic B, Klingenspor M, Klopstock T, Ollert M, Quintanilla-Martinez L, Schulz H, Wolf E, Wurst W, Zimmer A, Fisher SE, Morgenstern R, Arendt T, de Angelis MH, Fischer J, Schwarz J, Pääbo S. A humanized version of Foxp2 affects cortico-basal ganglia circuits in mice. Cell. 2009 137:961-71.

- Kurt S, Groszer M, Fisher SE, Ehret G. Modified sound-evoked brainstem potentials in Foxp2 mutant mice. Brain Res. 2009 1289:30-6.

2008

- Vernes SC, Newbury DF, Abrahams BS, Winchester L, Nicod J, Groszer M, Alarcón M, Oliver PL, Davies KE, Geschwind DH, Monaco AP, Fisher SE. A functional genetic link between distinct developmental language disorders. N Engl J Med. 2008 359:2337-45.

- Arnold SJ, Huang GJ, Cheung AF, Era T, Nishikawa S, Bikoff EK, Molnár Z, Robertson EJ, Groszer M. The T-box transcription factor Eomes/Tbr2 regulates neurogenesis in the cortical subventricular zone. Genes Dev. 2008 22:2479-84.

- Groszer M, Keays DA, Deacon RM, de Bono JP, Prasad-Mulcare S, Gaub S, Baum MG, French CA, Nicod J, Coventry JA, Enard W, Fray M, Brown SD, Nolan PM, Pääbo S, Channon KM, Costa RM, Eilers J, Ehret G, Rawlins JN, Fisher SE. Impaired synaptic plasticity and motor learning in mice with a point mutation implicated in human speech deficits. Curr Biol. 2008 18:354-62.

Selected Publications 2001-2007

- Vernes SC, Spiteri E, Nicod J, Groszer M, Taylor JM, Davies KE, Geschwind DH, Fisher SE. High-throughput analysis of promoter occupancy reveals direct neural targets of FOXP2, a gene mutated in speech and language disorders. Am J Hum Genet. 2007 81:1232-50.

- Francks C, Maegawa S, Laurén J, Abrahams BS, Velayos-Baeza A, Medland SE, Colella S, Groszer M, McAuley EZ, Caffrey TM, Timmusk T, Pruunsild P, Koppel I, Lind PA, Matsumoto-Itaba N, Nicod J, Xiong L, Joober R, Enard W, Krinsky B, Nanba E, Richardson AJ, Riley BP, Martin NG, Strittmatter SM, Möller HJ, Rujescu D, St Clair D, Muglia P, Roos JL, Fisher SE, Wade-Martins R, Rouleau GA, Stein JF, Karayiorgou M, Geschwind DH, Ragoussis J, Kendler KS, Airaksinen MS, Oshimura M, DeLisi LE, Monaco AP. LRRTM1 on chromosome 2p12 is a maternally suppressed gene that is associated paternally with handedness and schizophrenia. Mol Psychiatry. 2007 12:1129-39, 1057.

- French CA, Groszer M, Preece C, Coupe AM, Rajewsky K, Fisher SE. Generation of mice with a conditional Foxp2 null allele. Genesis. 2007 45:440-6.

- Freeman D, Lesche R, Kertesz N, Wang S, Li G, Gao J, Groszer M, Martinez-Diaz H, Rozengurt N, Thomas G, Liu X, Wu H. Genetic background controls tumor development in PTEN-deficient mice. Cancer Res. 2006 66:6492-6.

- Tsai PT, Ohab JJ, Kertesz N, Groszer M, Matter C, Gao J, Liu X, Wu H, Carmichael ST. A critical role of erythropoietin receptor in neurogenesis and post-stroke recovery. J Neurosci. 2006 26:1269-74.

- Groszer M, Erickson R, Scripture-Adams DD, Dougherty JD, Le Belle J, Zack JA, Geschwind DH, Liu X, Kornblum HI, Wu H. PTEN negatively regulates neural stem cell self-renewal by modulating G0-G1 cell cycle entry. Proc Natl Acad Sci U S A. 2006 103:111-6.

- Nakano I, Paucar AA, Bajpai R, Dougherty JD, Zewail A, Kelly TK, Kim KJ, Ou J, Groszer M, Imura T, Freije WA, Nelson SF, Sofroniew MV, Wu H, Liu X, Terskikh AV, Geschwind DH, Kornblum HI. Maternal embryonic leucine zipper kinase (MELK) regulates multipotent neural progenitor proliferation. J Cell Biol. 2005 170:413-27.

- Yue Q, Groszer M, Gil JS, Berk AJ, Messing A, Wu H, Liu X. PTEN deletion in Bergmann glia leads to premature differentiation and affects laminar organization. Development. 2005 132:3281-91.

- Stiles B, Groszer M, Wang S, Jiao J, Wu H. PTENless means more. Dev Biol. 2004 273:175-84. Review.

- Grimm C, Wenzel A, Stanescu D, Samardzija M, Hotop S, Groszer M, Naash M, Gassmann M, Remé C. Constitutive overexpression of human erythropoietin protects the mouse retina against induced but not inherited retinal degeneration. J Neurosci. 2004 24:5651-8.

- Tan M, Groszer M, Tan AM, Pandya A, Liu X, Xie CW. Phosphoinositide 3-kinase cascade facilitates mu-opioid desensitization in sensory neurons by altering G-protein-effector interactions. J Neurosci. 2003 23:10292-301.

- Grimm C, Wenzel A, Groszer M, Mayser H, Seeliger M, Samardzija M, Bauer C, Gassmann M, Remé CE. HIF-1-induced erythropoietin in the hypoxic retina protects against light-induced retinal degeneration. Nat Med. 2002 8:718-24.

- Lesche R, Groszer M, Gao J, Wang Y, Messing A, Sun H, Liu X, Wu H. Cre/loxP-mediated inactivation of the murine Pten tumor suppressor gene. Genesis. 2002 32:148-9.

- Groszer M, Erickson R, Scripture-Adams DD, Lesche R, Trumpp A, Zack JA, Kornblum HI, Liu X, Wu H. Negative regulation of neural stem/progenitor cell proliferation by the Pten tumor suppressor gene in vivo. Science. 2001 294:2186-9.

Publié le vendredi 18 janvier 2013

FLASH

For more see "Publications"

Some recent publications from IFM groups

Faure C, Ramos M, Girault JA. Pyk2 cytonuclear localization: mechanisms and regulation by serine dephosphorylation. (2013) Cell Mol Life Sci 70:137-52.

Alcacer C, Santini E, Valjent E, Gaven F, Girault JA, Herve D. Galpha(olf) mutation allows parsing the role of cAMP-dependent and extracellular signal-regulated kinase-dependent signaling in L-3,4-dihydroxyphenylalanine-induced dyskinesia. (2012) J Neurosci 32:5900-10.

Baudoin JP, Viou L, Launay PS, Luccardini C, Espeso Gil S, Kiyasova V, Irinopoulou T, Alvarez C, Rio JP, Boudier T, Lechaire JP, Kessaris N, Spassky N, Metin C. Tangentially Migrating Neurons Assemble a Primary Cilium that Promotes Their Reorientation to the Cortical Plate. (2012) Neuron 76:1108-22.

Bazelot M, Simonnet J, Dinocourt C, Bruel-Jungerman E, Miles R, Fricker D, Francis F. Cellular anatomy, physiology and epileptiform activity in the CA3 region of Dcx knockout mice: a neuronal lamination defect and its consequences. (2012) Eur J Neurosci 35:244-56.

Bellone C, Mameli M. mGluR-Dependent Synaptic Plasticity in Drug-Seeking. (2012) Front Pharmacol 3:159.

Bouthour W, Leroy F, Emmanuelli C, Carnaud M, Dahan M, Poncer JC, Levi S. A human mutation in Gabrg2 associated with generalized epilepsy alters the membrane dynamics of GABAA receptors. (2012) Cereb Cortex 22:1542-53.

Cabezas C, Irinopoulou T, Gauvain G, Poncer JC. Presynaptic But Not Postsynaptic GABA Signaling at Unitary Mossy Fiber Synapses. (2012) J Neurosci 32:11835-40.

Chamma I, Chevy Q, Poncer JC, Levi S. Role of the neuronal K-Cl co-transporter KCC2 in inhibitory and excitatory neurotransmission. (2012) Front Cell Neurosci 6:5.

Danglot L, Freret T, Le Roux N, Neme NN, Burgo A, Hyenne V, Roumier A, Contremoulins V, Dauphin F, Bizot JC, Vodjdani G, Gaspar P, Boulouard M, Poncer JC, Galli T, Simmler MC. Vezatin is essential for dendritic spine morphogenesis and functional synaptic maturation. (2012) J Neurosci 32:9007-22.

Despeaux M, Chicanne G, Rouer E, De Toni-Costes F, Bertrand J, Mansat-De Mas V, Vergnolle N, Eaves C, Payrastre B, Girault JA, Racaud-Sultan C. Focal adhesion kinase splice variants maintain primitive acute myeloid leukemia cells through altered wnt signaling. (2012) Stem Cells 30:1597-610.

Devaux S, Poulain FE, Devignot V, Lachkar S, Irinopoulou T, Sobel A. Specific serine-proline phosphorylation and glycogen synthase kinase 3beta-directed subcellular targeting of stathmin 3/Sclip in neurons. (2012) J Biol Chem 287:22341-53.

Diaz SL, Doly S, Narboux-Neme N, Fernandez S, Mazot P, Banas SM, Boutourlinsky K, Moutkine I, Belmer A, Roumier A, Maroteaux L. 5-HT(2B) receptors are required for serotonin-selective antidepressant actions. (2012) Mol Psychiatry 17:154-63.

Erzurumlu RS, Gaspar P. Development and critical period plasticity of the barrel cortex. (2012) Eur J Neurosci 35:1540-53.

Fernandez SP, Gaspar P. Investigating anxiety and depressive-like phenotypes in genetic mouse models of serotonin depletion. (2012) Neuropharmacology 62:144-54.

French CA, Jin X, Campbell TG, Gerfen E, Groszer M, Fisher SE, Costa RM. An aetiological Foxp2 mutation causes aberrant striatal activity and alters plasticity during skill learning. (2012) Mol Psychiatry 17:1077-85.

Fuchs T, Saunders-Pullman R, Masuho I, Luciano MS, Raymond D, Factor S, Lang AE, Liang TW, Trosch RM, White S, Ainehsazan E, Herve D, Sharma N, Ehrlich ME, Martemyanov KA, Bressman SB, Ozelius LJ. Mutations in GNAL cause primary torsion dystonia. (2012) Nat Genet 45:88-92.

Gangarossa G, Longueville S, De Bundel D, Perroy J, Herve D, Girault JA, Valjent E. Characterization of dopamine D1 and D2 receptor-expressing neurons in the mouse hippocampus. (2012) Hippocampus 22:2199-207.

Gaspar P, Lillesaar C. Probing the diversity of serotonin neurons. (2012) Philos Trans R Soc Lond B Biol Sci 367:2382-94.

Girault JA. Integrating neurotransmission in striatal medium spiny neurons. (2012) Adv Exp Med Biol 970:407-29.

Girault JA. Signaling in striatal neurons: the phosphoproteins of reward, addiction, and dyskinesia. (2012) Prog Mol Biol Transl Sci 106:33-62.

Godin JD, Thomas N, Laguesse S, Malinouskaya L, Close P, Malaise O, Purnelle A, Raineteau O, Campbell K, Fero M, Moonen G, Malgrange B, Chariot A, Metin C, Besson A, Nguyen L. p27(Kip1) is a microtubule-associated protein that promotes microtubule polymerization during neuron migration. (2012) Dev Cell 23:729-44.

Goebbels S, Oltrogge JH, Wolfer S, Wieser GL, Nientiedt T, Pieper A, Ruhwedel T, Groszer M, Sereda MW, Nave KA. Genetic disruption of Pten in a novel mouse model of tomaculous neuropathy. (2012) EMBO Mol Med 4:486-99.

Launay JM, Herve P, Callebert J, Mallat Z, Collet C, Doly S, Belmer A, Diaz SL, Hatia S, Cote F, Humbert M, Maroteaux L. Serotonin 5-HT2B receptors are required for bone-marrow contribution to pulmonary arterial hypertension. (2012) Blood 119:1772-80.

Lelievre EC, Plestant C, Boscher C, Wolff E, Mege RM, Birbes H. N-cadherin mediates neuronal cell survival through Bim down-regulation. (2012) PLoS One 7:e33206.

Manceau V, Kremmer E, Nabel EG, Maucuer A. The protein kinase KIS impacts gene expression during development and fear conditioning in adults. (2012) PLoS One 7(8):e43946.

Maroteaux M, Mameli M. Cocaine evokes projection-specific synaptic plasticity of lateral habenula neurons. (2012) J Neurosci 32:12641-6.

Mazot P, Cazes A, Dingli F, Degoutin J, Irinopoulou T, Boutterin MC, Lombard B, Loew D, Hallberg B, Palmer RH, Delattre O, Janoueix-Lerosey I, Vigny M. Internalization and down-regulation of the ALK receptor in neuroblastoma cell lines upon monoclonal antibodies treatment. (2012) PLoS One 7:e33581.

Meffre J, Chaumont-Dubel S, Mannoury la Cour C, Loiseau F, Watson DJ, Dekeyne A, Seveno M, Rivet JM, Gaven F, Deleris P, Herve D, Fone KC, Bockaert J, Millan MJ, Marin P. 5-HT(6) receptor recruitment of mTOR as a mechanism for perturbed cognition in schizophrenia. (2012) EMBO Mol Med 4:1043-56.

Mouton-Liger F, Paquet C, Dumurgier J, Bouras C, Pradier L, Gray F, Hugon J. Oxidative stress increases BACE1 protein levels through activation of the PKR-eIF2alpha pathway. (2012) Biochim Biophys Acta 1822:885-96.

Mouton-Liger F, Paquet C, Dumurgier J, Lapalus P, Gray F, Laplanche JL, Hugon J. Increased cerebrospinal fluid levels of double-stranded RNA-dependant protein kinase in Alzheimer's disease. (2012) Biol Psychiatry 71:829-35.

Narboux-Neme N, Evrard A, Ferezou I, Erzurumlu RS, Kaeser PS, Laine J, Rossier J, Ropert N, Sudhof TC, Gaspar P. Neurotransmitter release at the thalamocortical synapse instructs barrel formation but not axon patterning in the somatosensory cortex. (2012) J Neurosci 32:6183-96.

Paquet C, Mouton-Liger F, Meurs EF, Mazot P, Bouras C, Pradier L, Gray F, Hugon J. The PKR activator PACT is induced by Abeta: involvement in Alzheimer's disease. (2012) Brain Pathol 22:219-29.

Rebsam A, Bhansali P, Mason CA. Eye-specific projections of retinogeniculate axons are altered in albino mice. (2012) J Neurosci 32:4821-6.

Renner M, Schweizer C, Bannai H, Triller A, Levi S. Diffusion barriers constrain receptors at synapses. (2012) PLoS One 7:e43032.

Stacey D, et al. RASGRF2 regulates alcohol-induced reinforcement by influencing mesolimbic dopamine neuron activity and dopamine release. (2012) Proc Natl Acad Sci U S A 109:21128-21133.

Voyatzis S, Muzerelle A, Gaspar P, Nicol X. Modeling activity and target-dependent developmental cell death of mouse retinal ganglion cells ex vivo. (2012) PLoS One 7:e31105.